Conditions/Gut + microbiome/SIBO
— CONDITION · SMALL INTESTINAL BACTERIAL OVERGROWTH

SIBO.

Bacteria living in the wrong section of the intestine. Bloating, gas, food reactions — the picture clears once the location is corrected.

01 — WHAT IT IS

Right bugs. Wrong place.

SIBO is small intestinal bacterial overgrowth — bacteria that belong in the large intestine migrating up into the small intestine, where bacterial populations should normally be sparse. These displaced bacteria ferment carbohydrates prematurely, producing excess hydrogen, methane, or hydrogen sulfide gas that inflames the small intestinal lining.

That fermentation gas is the direct cause of the bloating, cramping, and unpredictable bowel changes that define the condition. The hallmark is bloating that gets worse through the day, especially after meals — often within 60 to 90 minutes of eating.

Research published in the American Journal of Gastroenterology found SIBO in up to 78% of patients carrying an IBS diagnosis, which suggests a large share of people labeled with IBS actually have an underlying, treatable bacterial overgrowth. Most SIBO patients have been told they have IBS for years before testing finally reveals the real driver.

Our functional medicine team in Jacksonville and Orange Park uses organic acid testing to identify what is actually overgrowing, then applies a botanical antimicrobial protocol paired with a mono-meal eating plan, repairs the gut lining alongside it, and reseeds only once the gut is ready and prevent relapse.

02 — SYMPTOMS

Does this sound familiar?

Bloating after meals
The stomach distends within an hour of eating and it gets worse as the day goes on.
Excessive gas
Frequent gas, both upper and lower, especially after carbohydrate-heavy meals.
Food reactivity
Foods that never used to bother you now do, and the list of triggers keeps growing.
Loose stools or constipation
Some people trend toward constipation, others toward diarrhea, and many alternate between the two.
Fatigue + brain fog after eating
Bacterial metabolites cross into circulation, producing low energy and cognitive sluggishness tied to poor nutrient absorption.
Iron or B12 deficiency
Overgrowth interferes with absorption upstream, causing deficiencies in iron, B12, and fat-soluble vitamins despite an adequate diet.
03 — HOW WE TREAT IT

Confirm. Clear. Reseed.

01
Organic acid testing
An organic acid urine test measures the metabolic by-products of the microbes fermenting your food — confirming overgrowth and showing whether bacteria, yeast, or oxalates are driving it. That result determines the entire protocol.
02
Targeted antimicrobials
Botanical antimicrobials — berberine and aromatic oils — paired with a mono-meal eating plan: one food per meal, organic meats and vegetables only. Removing the fermentation load while the antimicrobials work is what generic gut protocols miss.
03
Motility + diet support
SIBO almost always returns without addressing the migrating motor complex, so prokinetic support is essential — paired with a structured low-FODMAP or bi-phasic eating plan to reduce fermentation during clearance.
04
Reseed + repair
A phased restoration plan repairs the intestinal lining, strategically reintroduces diverse foods and probiotics, and rebuilds a healthy microbiome for long-term resilience.
04 — GOOD TO KNOW

Why bacteria overgrow in the first place

Your small intestine has built-in defenses that keep bacterial populations in check — stomach acid, digestive enzymes, and the migrating motor complex, the wave-like contractions that sweep bacteria downstream between meals. SIBO develops when those defenses fail.

The usual mechanical drivers: impaired gut motility (a slow migrating motor complex), structural abnormalities like adhesions or strictures, low stomach acid — frequently from chronic proton pump inhibitor use — post-surgical changes to GI anatomy, and systemic conditions like diabetes or hypothyroidism that affect the gut's nerve function. Immune dysfunction can contribute as well.

Why it's so often mislabeled as IBS

Standard gastroenterology workups rarely look for fermentation at all, so the overgrowth that defines SIBO goes unmeasured. Patients get an IBS label — which describes the symptoms without identifying the cause — and cycle through diets and medications that manage rather than resolve the problem.

That matters because SIBO is treatable in a way that a vague IBS diagnosis is not. Identifying the specific gas pattern points to the right antimicrobial and the right dietary strategy, which is the difference between chasing symptoms and actually clearing the overgrowth.

Preventing relapse after treatment

Clearing the overgrowth is only half the job. Because the underlying motility problem is usually what allowed bacteria to accumulate in the first place, SIBO has a real tendency to return if that root cause is ignored.

This is why prokinetic support to restore the migrating motor complex, plus attention to stomach acid and diet, is built into the plan from the start. A gut-healing phase then rebuilds the lining and microbiome so the improvement holds rather than fading within a few months.

What a SIBO evaluation looks like

A SIBO evaluation starts with organic acid testing, a urine panel that measures the metabolic by-products your gut microbes release as they ferment food. It tells us not only whether overgrowth is present but whether bacteria, yeast, or oxalate handling is driving it — and that distinction shapes the entire protocol.

Alongside testing, we take a detailed history: prior abdominal surgery, PPI use, thyroid function, and the timing of your bloating all help explain why the overgrowth took hold. Comprehensive lab panels round out the picture where nutrient deficiencies or thyroid involvement are suspected.

From diagnosis through resolution, our team guides each phase — confirm the pattern, clear the overgrowth, restore motility, then reseed and repair — so you're never left guessing what the next step is or why it matters.

You were told it is IBS. It might be SIBO.

SIBO mimics IBS almost perfectly — the same bloating, pain, diarrhea, and constipation. The difference is that IBS is a description of symptoms while SIBO is an identifiable, treatable cause. Research suggests up to 78% of people diagnosed with IBS actually have bacterial overgrowth driving the picture.

If you have spent years on fiber supplements, peppermint capsules, and a low-FODMAP diet that helped for a while and then stopped, that plateau is the tell. Managing IBS without lasting improvement is a reason to test for what might actually be underneath it.

How bacteria end up where they do not belong

Your body has built-in defenses to keep bacteria in the colon and out of the small intestine. SIBO develops when those defenses fail. The most common failure is an impaired migrating motor complex — the cleaning wave that sweeps bacteria downstream between meals. Low stomach acid from PPI use, aging, or chronic stress also lets bacteria survive and climb.

Other drivers include structural issues such as surgical adhesions or ileocecal valve dysfunction, nerve damage from a bout of food poisoning (post-infectious IBS), hypothyroidism slowing gut transit, and chronic stress reducing digestive secretions. Understanding which one applies to you is the key to preventing recurrence.

Why probiotics sometimes make it worse

One counterintuitive clue: you tried probiotics because someone said they would help, and instead you felt worse — more bloating, more gas. When bacteria are already overgrown in the wrong place, adding more can aggravate the problem. That reaction is a red flag that points toward SIBO rather than away from it.

This is why sequence matters. Reintroducing beneficial bacteria has a place, but only after the overgrowth is cleared and motility is restored — not before.

How long SIBO treatment takes

An antimicrobial round typically lasts 4 to 6 weeks, and some patients need a second round. Motility support then continues for 3 to 6 months after clearance to prevent relapse.

We re-evaluate at day 10 and retest to confirm the overgrowth is actually clearing — not just that symptoms improved. Confirming it objectively is what keeps you from cycling back into the same problem a few months later.

05 — COMMON QUESTIONS

Questions, answered.

What is SIBO?
SIBO stands for Small Intestinal Bacterial Overgrowth — a condition where bacteria that normally live in the large intestine migrate to and overgrow in the small intestine. This disrupts digestion and nutrient absorption and is a well-documented cause of IBS symptoms.
What causes SIBO?
SIBO is caused by impaired small intestinal motility, structural abnormalities, low stomach acid (often from PPI use), prior abdominal surgery, immune dysfunction, or hypothyroidism. Conditions that slow the migrating motor complex — the wave-like contractions that clear bacteria from the small intestine — are the primary mechanical drivers of SIBO.
What are the symptoms of SIBO?
SIBO symptoms include bloating that worsens after eating, abdominal pain, excessive gas, diarrhea, constipation, or alternating bowel habits. Many patients also experience fatigue, brain fog, and nutritional deficiencies — particularly B12 and fat-soluble vitamins — due to bacterial interference with absorption.
How is SIBO diagnosed?
SIBO and fungal overgrowth are identified here with organic acid testing — a urine panel that measures the metabolic by-products bacteria and yeast leave behind as they ferment your food. It shows whether bacterial overgrowth, yeast, or oxalate handling is driving the picture, and that answer determines which protocol you go on. Bloodwork runs alongside it to fill in nutrient status and inflammation.
Does SIBO cause bloating?
Yes. Bloating is one of the most consistent symptoms of SIBO. The bacteria in the small intestine ferment carbohydrates before they can be absorbed, producing gas that causes bloating, distension, and discomfort — often within 60 to 90 minutes of eating.
Can SIBO be cured?
SIBO can be successfully treated with antimicrobial protocols — either pharmaceutical (rifaximin, neomycin) or herbal (berberine, allicin, oregano oil) — followed by prokinetic therapy to restore motility and prevent relapse, and gut restoration to re-establish a healthy microbiome. Addressing the root cause (motility, stomach acid, diet) is essential for preventing recurrence. Meridian offers SIBO testing and treatment in Jacksonville, FL.
Is my IBS actually SIBO?
It may well be. Research published in the American Journal of Gastroenterology suggests up to 78% of IBS patients actually have SIBO. If you have managed an IBS diagnosis for years without real improvement, organic acid testing can reveal whether bacterial overgrowth is the underlying driver.
Why do probiotics make my bloating worse?
If probiotics worsen your bloating and gas, it can be a sign of SIBO. When bacteria are already overgrown in the small intestine, adding more bacteria can aggravate the fermentation. That reaction is a reason to test for SIBO before continuing probiotics.
How long does SIBO treatment take?
An antimicrobial treatment round typically lasts 4 to 6 weeks, and some patients need a second round. Motility support continues for 3 to 6 months after clearance to prevent relapse, and we retest to confirm eradication rather than relying on symptoms alone.
Why does SIBO keep coming back?
SIBO recurs when the underlying cause is not addressed — most often an impaired migrating motor complex, the gut's cleaning wave between meals. Killing the bacteria without restoring motility and fixing the root cause (low stomach acid, thyroid issues, adhesions, or post-infection nerve damage) leads to the treat-relapse-treat cycle. Root-cause prevention is the goal.
— IF YOU'RE READY

Test, don't guess.

A 30-minute consult to determine if SIBO testing is appropriate and the steps to confirm or rule it out.

Book a SIBO consult